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首页> 外文OA文献 >Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country
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Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country

机译：补充锌可降低极低出生体重早产儿的发病率和死亡率：在工业化国家进行的基于医院的随机，安慰剂对照试验

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Background: Zinc plays a pivotal role in the pathogenesis of many diseases and in body growth. Preterm neonates have high zinc requirements. Objective: The objective of the study was to investigate the efficacy of zinc supplementation in reducing morbidity and mortality in preterm neonates and to promote growth. Design: This was a prospective, double-blind, randomized controlled study of very-low-birth-weight preterm neonates randomly allocated on the seventh day of life to receive (zinc group) or not receive (control group) oral zinc supplementation. Total prescribed zinc intake ranged from 9.7 to 10.7 mg/d in the zinc group and from 1.3 to 1.4 mg/d in the placebo control group. The main endpoint was the rate of neonates with >= 1 of the following morbidities: late-onset sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, periventricular leucomalacia, and retinopathy of prematurity. Secondary outcomes were mortality and body growth. Results: We enrolled 97 neonates in the zinc group and 96 in the control group. Morbidities were significantly lower in the zinc group (26.8% compared with 41.7%; P = 0.030). The occurrence of necrotizing enterocolitis was significantly higher in the control group (6.3% compared with 0%; P = 0.014). Mortality risk was higher in the placebo control group (RR: 2.37; 95% CI: 1.08, 5.18; P = 0.006). Daily weight gain was similar in the zinc (18.2 +/- 5.6 g . kg(-1) . d(-1)) and control (17.0 +/- 8.7 g . kg(-1) . d(-1)) groups (P = 0.478). Conclusion: Oral zinc supplementation given at high doses reduces morbidities and mortality in preterm neonates.
机译：背景：锌在许多疾病的发病机理和人体生长中起着关键作用。早产儿对锌的需求很高。目的：该研究的目的是研究补锌在降低早产儿发病率和死亡率以及促进生长方面的功效。设计：这项前瞻性，双盲，随机对照研究对出生后第七天随机分配接受（锌组）或不接受（对照组）口服锌补充剂的极低出生体重早产儿进行了研究。锌组的总规定锌摄入量为9.7至10.7 mg / d，安慰剂对照组为1.3至1.4 mg / d。主要终点指标是以下疾病的≥1的新生儿比率：迟发性败血症，坏死性小肠结肠炎，支气管肺发育不良，室周白细胞软化和早产儿视网膜病变。次要结果是死亡率和身体生长。结果：我们在锌组中招募了97名新生儿，在对照组中招募了96名新生儿。锌组的发病率显着降低（26.8％，而41.7％； P = 0.030）。对照组中坏死性小肠结肠炎的发生率显着更高（6.3％比0％； P = 0.014）。安慰剂对照组的死亡率风险较高（RR：2.37； 95％CI：1.08、5.18； P = 0.006）。锌（18.2 +/- 5.6 g。kg（-1）。d（-1））和对照（17.0 +/- 8.7 g。kg（-1）。d（-1））的每日体重增加相似组（P = 0.478）。结论：大剂量口服锌补充剂可降低早产儿的发病率和死亡率。

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